The author of 《Mitochondria-localized iridium(III) complexes with anthraquinone groups as effective photosensitizers for photodynamic therapy under hypoxia》 were Guo, Song; Han, Meiping; Chen, Ruizhe; Zhuang, Yanling; Zou, Liang; Liu, Shujuan; Huang, Wei; Zhao, Qiang. And the article was published in Science China: Chemistry in 2019. Electric Literature of C5H3Br2N The author mentioned the following in the article:
Photodynamic therapy (PDT) is a potential way for the tumor treatment. However, it notably suffers the limitation of hypoxia in solid tumors. Thus, it is significant to develop effective photosensitizers which can exhibit excellent therapeutic performance under both normoxia and hypoxia. Herein, we reported four ionic iridium(III) complexes (Ir1-Ir4) with anthraquinone groups which can regulate their excited state energy levels effectively. Among them, the energy gap of Ir1 was between 1.63 and 2.21 eV, which can match well with that of O2, and the HOMO energy of Ir1 is less than -5.51 eV. Compared with Ir2-Ir4, the luminescent quantum efficiency of Ir1 was the highest. Particularly, Ir1 can specifically target the mitochondria of the tumor cells. Meanwhile, Ir1 showed high singlet oxygen quantum yields (φΔ) in both solutions and living cells with low cytotoxicity. The results of PDT experiments revealed that Ir1, as a photosensitizer, exhibited excellent therapeutic effect not only in normoxia but also in hypoxia condition. We believe that this work is meaningful for developing excellent PDT agents based on cyclometalated Ir(III) complexes via rational ligand modification. In the experiment, the researchers used many compounds, for example, 2,5-Dibromopyridine(cas: 624-28-2Electric Literature of C5H3Br2N)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Electric Literature of C5H3Br2N