Guo, Xuelei published the artcileNickel-Catalyzed Suzuki-Miyaura Cross-Coupling Facilitated by a Weak Amine Base with Water as a Cosolvent, Quality Control of 321438-86-2, the main research area is nickel catalyst preparation Suzuki coupling reaction amine water cosolvent; aryl chloride Suzuki coupling aryl boronic acid water cosolvent; pharmaceutical substrate nickel catalyzed Suzuki cross coupling.
The development of a Ni-catalyzed Suzuki-Miyaura cross-coupling that uses a weak amine base and performs optimally with H2O as a cosolvent is reported. The aqueous amine base facilitates an equilibrium between the Ni oxidative addition complex and Ni μ-hydroxo dimers, enabling productive catalysis at low metal loadings (typically 1 mol %). A practical catalytic system is enabled using a com. available Ni oxidative addition complex as a precatalyst. The mild conditions allow high functional group tolerance and application to complex pharmaceutical substrates, one of which was demonstrated on a 50 g scale with a catalyst loading of 0.5 mol %.
Organometallics published new progress about Amines Role: RGT (Reagent), RACT (Reactant or Reagent) (weak). 321438-86-2 belongs to class pyridine-derivatives, name is 6-(Methylthio)pyridin-3-ylboronic acid, and the molecular formula is C6H8BNO2S, Quality Control of 321438-86-2.