Gurgul, Ilona; Mazuryk, Olga; Stachyra, Kamila; Olszanecki, Rafal; Lekka, Malgorzata; Lomzik, Michal; Suzenet, Franck; Gros, Philippe C.; Brindell, Malgorzata published the artcile< Impact of Polypyridyl Ru Complexes on Angiogenesis-Contribution to Their Antimetastatic Activity>, HPLC of Formula: 366-18-7, the main research area is angiogenesis; cell adhesion properties; cell elasticity; cytotoxicity; endothelial cells; focal adhesions; migration; polypyridyl ruthenium (II) complexes; pseudovessel formation.
The use of polypyridyl Ru complexes to inhibit metastasis is a novel approach, and recent studies have shown promising results. We have reported recently that Ru (II) complexes gathering two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and the one being 2,2′-bipyridine (bpy) or its derivative with a 4-[3-(2-nitro-1H-imidazol-1-yl)propyl (bpy-NitroIm) or 5-(4-{4′-methyl-[2,2′-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moieties can alter the metastatic cascade, among others, by modulating cell adhesion properties. In this work, we show further studies of this group of complexes by evaluating their effect on HMEC-1 endothelial cells. While all the tested complexes significantly inhibited the endothelial cell migration, Ru-bpy addnl. interrupted the pseudovessels formation. Functional changes in endothelial cells might arise from the impact of the studied compounds on cell elasticity and expression of proteins (vinculin and paxillin) involved in focal adhesions. Furthermore, mol. studies showed that complexes modulate the expression of cell adhesion mols., which has been suggested to be one of the factors that mediate the activation of angiogenesis. Based on the performed studies, we can conclude that the investigated polypyridyl Ru (II) complexes can deregulate the functionality of endothelial cells which may lead to the inhibition of angiogenesis.
International Journal of Molecular Sciences published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.