The author of 《General synthesis of primary amines via reductive amination employing a reusable nickel catalyst》 were Hahn, G.; Kunnas, P.; de Jonge, N.; Kempe, R.. And the article was published in Nature Catalysis in 2019. Application of 1122-54-9 The author mentioned the following in the article:
A nanostructured nickel catalyst was reported for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. The catalyst, which operated at low temperature and pressure, was highly active, reusable and easy to handle. The synthesis from a specific nickel complex and γ-Al2O3 was straightforward, with the ligand-metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl-alkyl, dialkyl and diaryl ketones could all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products was demonstrated. Many functional groups-including hydrogenation-sensitive examples-were tolerated. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1122-54-9