《Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted L-Pipecolic Acids》 was written by Hai, Yang; Chen, Mengbin; Huang, Arthur; Tang, Yi. Computed Properties of C6H5NO2 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:
Fusaric acid (FA) is a known mycotoxin that plays an important role in plant pathol. The biosynthetic gene cluster for FA was identified, but the biosynthetic pathway remains unclarified. Here, the authors elucidated the biosynthesis of FA, which features a two-enzyme catalytic cascade, a pyridoxal 5′-phosphate (PLP)-dependent enzyme (Fub7), and a FMN-dependent oxidase (Fub9) in synthesizing the picolinic acid scaffold. FA biosynthesis also involves an off-line collaboration between a highly reducing polyketide synthase (HRPKS, Fub1) and a nonribosomal peptide synthetase (NRPS)-like carboxylic acid reductase (Fub8) in making an aliphatic α,β-unsaturated aldehyde. By harnessing the stereoselective C-C bond-forming activity of Fub7, the authors established a chemoenzymic route for stereoconvergent synthesis of a series of 5-alkyl-, 5,5-dialkyl-, and 5,5,6-trialkyl-L-pipecolic acids of high diastereomeric ratio. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Computed Properties of C6H5NO2