Handa, Sachin; Andersson, Martin P.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. published the artcile< HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-catalyzed Cross-Couplings in Water at Room Temperature>, HPLC of Formula: 13472-84-9, the main research area is monophosphine palladium catalyst coupling Suzuki Miyaura; E Factor; Suzuki-Miyaura coupling; green chemistry; ligand design; micellar catalysis.
The new monophosphine ligand HandaPhos was identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly functionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures Comparisons with existing state-of-the-art ligands and catalysts are discussed herein.
Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, HPLC of Formula: 13472-84-9.