HPLC of Formula: 128071-75-0In 2022 ,《Iodine-Mediated C=C Double Bond Cleavage toward Pyrido[2,1-b]quinazolinones》 appeared in Organic Letters. The author of the article were Hao, Wei; Li, Kailu; Ye, Chenyang; Yu, Wenquan; Chang, Junbiao. The article conveys some information:
A transition-metal-free C=C double bond cleavage reaction employing mol. iodine is described. In the presence of K2CO3 as the base, I2-mediated C = C bond cleavage followed by intramol. annulation of N-(2-vinylaryl)pyridin-2-amine substrates, e.g., N-(2-vinylnaphthalen-1-yl)pyridin-2-amine produces pyrido[2,1-b]quinazolinones, e.g., 7H-benzo[h]pyrido[2,1-b] quinazolin-7-one and related heterocyclic compounds This reaction can be completed on a gram scale and has been successfully applied to the synthesis of compounds with important biol. properties such as 11H-pyrido[2,1-b]quinazolin-11-one and 2-methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, including efflux pump inhibitory and antiallergic activities. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 128071-75-0