Reaction of aromatic N-oxides with dipolarophiles. VI. Further studies on the 1,3-dipolar cycloaddition reaction of pyridine N-oxides with phenyl isocyanates was written by Harano, Kazunobu;Suematsu, Fumihiro;Matsuoka, Toshikazu;Hisano, Takuzo. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Related Products of 3718-65-8 This article mentions the following:
To provide addnl. evidence for the concerted mechanism postulated for the 1,3-dipolar cycloaddition reaction of pyridine N-oxides with Ph isocyanates, kinetic studies on the cycloaddition reactions were conducted in a variety of solvents. The cycloaddition showed low sensitivity to the ionizing power of the medium, indicating that it proceeds by a mechanism which involves very little change in charge separation between the ground state and the transition state. The observed cycloadditivity and site selectivity are discussed in terms of the following controlling factors based on MINDO/3 calculations: HOMO-LUMO control, secondary orbital interaction, steric interaction, dipole-dipole interaction, and charge-transfer complexation. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Related Products of 3718-65-8).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 3718-65-8