Harper, Kaid C.; Vilardi, Sarah C.; Sigman, Matthew S. published an article on February 20 ,2013. The article was titled 《Prediction of Catalyst and Substrate Performance in the Enantioselective Propargylation of Aliphatic Ketones by a Multidimensional Model of Steric Effects》, and you may find the article in Journal of the American Chemical Society.Computed Properties of C7H11ClN2 The information in the text is summarized as follows:
The effectiveness of a new asym. catalytic methodol. is often weighed by the number of diverse substrates that undergo reaction with high enantioselectivity. Here we report a study that correlates substrate and ligand steric effects to enantioselectivity for the propargylation of aliphatic ketones. The math. model is shown to be highly predictive when applied to substrate/catalyst combinations outside the training set. After reading the article, we found that the author used (6-Methylpyridin-2-yl)methanamine hydrochloride(cas: 1365836-53-8Computed Properties of C7H11ClN2)
(6-Methylpyridin-2-yl)methanamine hydrochloride(cas: 1365836-53-8) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C7H11ClN2