Preparation of isopropyl- and tert-butylpyridines from methylpyridines by phase-transfer catalyzed alkylation was written by Hart, Lionel S.;Killen, Christopher R. J.;Saunders, Kenwyn D.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1979.Application In Synthesis of 2-Isopropylpyridine This article mentions the following:
2-Methylpyridine on quaternization with MeI, followed by alkylation with MeI in aqueous NaOH/CH2Cl2 catalyzed by Bu4N+ OH– and dequaternization with 4-MeC6H4SNa (I), gave 36% 2-isopropylpyridine. Similar sequential quaternization, phase-transfer-catalyzed methylation and dequaternization of 2,6-dimethylpyridine gave 40% 2,6-diisopropylpyridine, whereas 4-methylpyridine gave 37% 4-tert-butylpyridine. 4-tert-Butyl-2,6-diisopropylpyridine was similarly obtained (20%) from 2,4,6-trimethylpyridine. Contact with a CH2Cl2 solution of the dequaternization products may lead to an allergic reaction resulting in extreme sensitivity to contact with I. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application In Synthesis of 2-Isopropylpyridine).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 2-Isopropylpyridine