Dual Photoredox/Palladium-Catalyzed C-H Acylation of 2-Arylpyridines with Oxime Esters was written by He, Bin-Qing;Gao, Yuan;Wang, Peng-Zi;Wu, Hong;Zhou, Hong-Bin;Liu, Xiao-Peng;Chen, Jia-Rong. And the article was included in Synlett in 2021.Electric Literature of C12H11N This article mentions the following:
An unprecedented dual photoredox/palladium-catalyzed iminyl-radical-mediated C-C bond cleavage and directed orthoC-H acylation of 2-arylpyridines by using oxime esters was described. Oxime esters was serve as efficient acyl sources through formation of the corresponding acyl radicals by photoredox-catalyzed iminyl-radical-mediated C-C bond cleavage. This redox-neutral protocol features excellent regioselectivity, a broad substrate scope, and good functional-group tolerance with respect to both components, giving a broad range of aryl ketones with generally good yields. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Electric Literature of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C12H11N