《Synthesis, Biological Evaluation, and Molecular Docking of Arylpyridines as Antiproliferative Agent Targeting Tubulin》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to He, JiaPeng; Zhang, Mao; Tang, Lv; liu, Jie; Zhong, JiaHong; Wang, Wenya; Xu, Jiang-Ping; Wang, Hai-Tao; Li, Xiao-Fang; Zhou, Zhong-Zhen. SDS of cas: 128071-75-0 The article mentions the following:
Mimicking different pharmacophoric units into one scaffold is a promising structural modification tool to design new drugs with enhanced biol. properties. To continue our research on the tubulin inhibitors, the synthesis and biol. evaluation of arylpyridine derivatives are described herein. Among these compounds, 6-arylpyridines bearing benzo[d]imidazole side chains at the 2-position of pyridine ring displayed selective antiproliferative activities against HT-29 cells. More interestingly, 2-trimethoxyphenylpyridines, e.g., I, bearing benzo[d]imidazole and benzo[d]oxazole side chains displayed more broad-spectrum antitumor activities against all tested cancer cell lines. I bearing a 6-methoxybenzo[d]oxazole group exhibited comparable activities against A549 and U251 cells to combretastatin A-4 (CA-4) and lower cytotoxicities than CA-4 and 5-Fu. Further investigations revealed I displays strong tubulin polymerization inhibitory activity (IC50 = 2.1μM) and effectively binds at the colchicine binding site and arrests the cell cycle of A549 in the G2/M phase by disrupting the microtubules network. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 128071-75-0