Hebel, David; Rozen, Shlomo published the artcile< Utilizing acetyl hypofluorite for chlorination, bromination, and etherification of the pyridine system>, HPLC of Formula: 13472-84-9, the main research area is pyridine chlorination acetyl hypofluorite; etherification pyridine acetyl hypofluorite; bromination pyridine acetyl hypofluorite.
AcOF, which is easily made from F2, possesses a strong electrophilic fluorine. This electrophile is able to attach itself to the nitrogen atom of pyridine and activate the ring toward nucleophilic attacks. The ultimate elimination of HF results in an overall easy nucleophilic displacement of the hydrogen of the important 2-position. The nucleophiles used, originate from solvents such as CH2Cl2, CH2Br2, and various primary alcs. Thus, 2-halo- or 2-alkoxypyridines are formed. The reaction conditions (room temperature, very short reaction times, and good yields) transform the task of direct substitution of the pyridine ring from an extremely difficult to a very easy procedure.
Journal of Organic Chemistry published new progress about Bromination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, HPLC of Formula: 13472-84-9.