Hedou, Damien; Voisin-Chiret, Anne Sophie published an article in European Journal of Organic Chemistry. The title of the article was 《Br vs. TsO Chemoselective Suzuki-Miyaura Cross-Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2,3,5-Trisubstituted Pyridines》.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid The author mentioned the following in the article:
Br vs. TsO chemoselective pallado-catalyzed Suzuki-Miyaura reaction has been developed from the 5-bromo-2-tosyloxynicotinaldehyde for the preparation of polysubstituted pyridines. This methodol. has been applied for the preparation of a terpyridine aldehyde, as a versatile precursor of potential Mcl-1 (Induced myeloid leukemia cell differentiation protein) inhibitors. The synthesis of pyridoclax (I), our lead compound which demonstrated efficacy for the treatment of chemoresistant ovarian cancer, has also been achieved via the palladium-catalyzed cross-coupling reaction in 5 steps from 3,5-dibromo-2-hydroxypyridine with 50% overall yield.(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid) was used in this study.
(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid