On March 1, 1987, Heinisch, Gottfried; Loetsch, Gerhard published an article.Synthetic Route of 97483-79-9 The title of the article was Homolytic alkoxycarbonylation reactions in two-phase systems. 3. Introduction of a single carboxylic acid ester function into cyano- or (alkoxycarbonyl)-substituted N-heteroaromatics. And the article contained the following:
Radical alkoxycarbonylation of pyridines I (R = cyano, CO2Et, R1-R3 = H; R = R2 = R3 = H, R1 = cyano, CO2Et; R = R1 = R3 = H, R2 = cyano, CO2Et) with MeCOCO2Me or MeCOCO2Et in H2O-CH2Cl2 containing H2O2-FeSO4 gave mainly monosubstitution products. Thus, I (R = cyano, R1-R3 = H) was treated with MeCOCO2Et to give 34% I (R = cyano, R1 = R3 = H, R2 = CO2Et) and 13% I (R = cyano, R1 = R2 = H, R3 = CO2Et). Similarly, I (R = R2 = R3 = H, R1 = CO2Et) reacted with MeCOCO2Me to give 29% I (R = CO2Me, R1 = CO2Et, R2 = R3 = H), 36% I (R = R3 = H, R1 = CO2Et, R2 = CO2Me), and 20% I (R = R2 = H, R1 = CO2Et, R3 = CO2Me). Only the mixed ester I (R = CO2Me, R1 = R3 = H, R2 = CO2Et) was obtained (in 81% yield) by treating I (R = R1 = R3 = H, R2 = CO2Et) with MeCOCO2Me. The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Synthetic Route of 97483-79-9
The Article related to pyridine alkoxycarbonyl cyano, cyanopyridinecarboxylate, pyridazinedicarboxylate, homolytic alkoxycarbonylation cyanopyridine pyruvate, radical alkoxycarbonylation pyridinecarboxylate pyruvate and other aspects.Synthetic Route of 97483-79-9