《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》 was written by Heinrich, Timo; Sala-Hojman, Ada; Ferretti, Roberta; Petersson, Carl; Minguzzi, Stefano; Gondela, Andrzej; Ramaswamy, Shivapriya; Bartosik, Anna; Czauderna, Frank; Crowley, Lindsey; Wahra, Pamela; Schilke, Heike; Boepple, Pia; Dudek, Lukasz; Les, Marcin; Niedziejko, Paulina; Olech, Kamila; Pawlik, Henryk; Wloszczak, Lukasz; Zuchowicz, Karol; Suarez Alvarez, Jose Ramon; Martyka, Justyna; Sitek, Ewa; Mikulski, Maciej; Szczesniak, Joanna; Jaeckel, Sven; Krier, Mireille; Krol, Marcin; Wegener, Ansgar; Galezowski, Michal; Nowak, Mateusz; Becker, Frank; Herhaus, Christian. Recommanded Product: 39856-58-1 And the article was included in Journal of Medicinal Chemistry on August 26 ,2021. The article conveys some information:
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 39856-58-1)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 39856-58-1