Hemati, Tahereh published the artcileActivation of L-type calcium channels and attenuation of oxidative stress are involved in the improving effect of methyl jasmonate on learning and memory and its anxiolytic property in rats, Related Products of pyridine-derivatives, the main research area is anxiety learning oxidative stress calcium channel methyl jasmonate.
The present study was designed to evaluate the effect of plant bioactive compound Me jasmonate on learning and memory, anxiety-like behaviors, and brain oxidative stress in rats. Therefore, we investigated the potential role of L-type calcium channel on Me jasmonate effects. The animals were intracerebroventriculary (i.c.v.) injected with different doses of Me jasmonate (0.5, 2.5, and 5μg/rat). L-type calcium channel blocker (nifedipine 5μg/rat, i.c.v.) was injected 30 min before Me jasmonate (5μg/rat). Shuttle box apparatus was used to evaluate passive avoidance memory. Anxiety-like behaviors were assessed by open field and elevated plus maze tests. Lastly, oxidative stress-related indexes were assessed in hippocampus and prefrontal cortex. The data showed that Me jasmonate dose-dependently could improve passive avoidance learning and memory and reduce anxiogenic behaviors. The Me jasmonate effects were significantly prevented by nifedipine. Furthermore, central microinjection of Me jasmonate significantly decreased hydrogen peroxide concentration, and increased reactive oxygen species scavenger activity (catalase and peroxide enzymes) in rats’ hippocampus as well as prefrontal cortex. Indeed, the results indicated that the beneficial effects of Me jasmonate on learning and memory and anxiety might be partly associated with L-type calcium channel and partly on the inhibition of oxidant indexes.
Behavioural Pharmacology published new progress about Anxiety. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.