Thermal interaction of linoleic acid and its esters with valine was written by Henderson, S. K.;Nawar, W. W.. And the article was included in JAOCS, J. Am. Oil Chem. Soc. in 1981.Application In Synthesis of 4-Hexylpyridine This article mentions the following:
When linoleic acid or its esters were heated in the presence of valine, a number of products were formed. The major product was 2-pentylpyridine, which was produced by the reaction of 2,4-decadienal with ammonia. Also formed were isobutyloctanamide and isobutylinoleylamide. Addnl. products include alkylpyridines and alkylpyrrole. They can result by reaction of an aldehyde with an amine or ammonia to form a Schiff base, followed by cyclization and rearrangement to form either the pyridine ring of the pyrrole ring. In addition, a branched nitrile compound was produced which was formed by cleavage of the pyridine ring in 2-pentylpyridine. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application In Synthesis of 4-Hexylpyridine).
4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 4-Hexylpyridine