Herrera, Christian Leonardo; Santiago, Joao Victor; Pastre, Julio Cezar; Correia, Carlos Roque Duarte published the artcile< In Tandem Auto-Sustainable Enantioselective Heck-Matsuda Reactions Directly from Anilines>, Computed Properties of 1416819-91-4, the main research area is aniline cyclopentenol palladium catalyst enantioselective Heck Matsuda reaction green; phenyl cyclopentenol preparation; cyclopentenedicarboxylate aniline palladium catalyst enantioselective Heck Matsuda reaction green; dimethyl phenyl cyclopentenedicarboxylate preparation; butenediol aniline palladium catalyst enantioselective Heck Matsuda reaction green; aryl furanone preparation.
An in tandem enantioselective Heck-Matsuda (HM) reaction of cyclic and acyclic olefins directly from anilines was described. The method relied on a process involving the progressive in situ diazotization of the starting anilines followed by a palladium-catalyzed Heck-Matsuda arylation using chiral N,N-ligands. This intermol. enantioselective HM arylation strategy was applied to the desymmetrization of three distinct unactivated olefins as proof of concept. The method demonstrates broad substrate scope furnishing the Heck adducts in good to excellent enantiomeric ratios of up to 99:1, high diastereoselectivities (cyclopenten-3-ol with>20:1 dr), and good overall yields of up to 82% over 2 or 3 steps.
Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Computed Properties of 1416819-91-4.