On January 9, 2003, Hoegberg, Thomas; Rist, Oystein; Hjelmencrantz, Anders; Moldt, Peter; Elling, Christian E.; Schwartz, Thue W.; Gerlach, Lars Ole; Holst Lange, Birgitte published a patent.Recommanded Product: 75449-26-2 The title of the patent was Metal ion binding-based chemical libraries useful for drug discovery processes. And the patent contained the following:
The invention discloses the use of chem. compounds or selections of chem. compounds (libraries) of the general formula R1XFY(R1)GZR1 [F, G = N, O, S, Se, P; X, Y, Z = (un)branched C1-12 alkyl, (hetero)aryl, etc.; R1 = H, ABC; A = coupling or connecting moiety; B = spacer moiety; C = functional group] for in vivo methods for testing or validating the physiol. importance and/or the therapeutic or pharmacol. potential of biol. target mols., notably proteins such as, e.g., receptors and especially 7TM receptors in test animals expressing the biol. target mol. with, notably, a silent, engineered metal ion site. Use of specific metal ion binding sites of a generic nature in specific biol. target mols. such as, e.g. transmembrane proteins wherein the metal-ion binding site is capable of forming a complex with a metal ion is also described. The invention provides chem. compounds or libraries suitable for use in methods for improving the in vivo pharmacokinetic behavior of metal-ion chelates (e.g. the absorption pattern, the plasma half-life, the distribution, the metabolism and/or the elimination of the metal ion chelates). In order to improve the efficacy of the metal ion chelates impact on the biol. target mol. after administration of the metal ion chelate in vivo to a test animal, it is advantageous e.g. to increase the time period during which the metal ion chelate is in the circulatory system and/or localized at the target. Metal ion chelating compounds, which are designed to be suitable for use in a target validation process according to the invention and to libraries of at least two or more of such metal-ion chelating compounds are disclosed. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: 75449-26-2
The Article related to metal chelate library drug discovery, target protein drug discovery metal chelate library, receptor target drug discovery metal chelate library, Pharmacology: Methods and other aspects.Recommanded Product: 75449-26-2