Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice was written by Holladay, Mark W.;Bai, Hao;Li, Yihong;Lin, Nan-Horng;Daanen, Jerome F.;Ryther, Keith B.;Wasicak, James T.;Kincaid, John F.;He, Yun;Hettinger, Anne-Marie;Huang, Peggy;Anderson, David J.;Bannon, Anthony W.;Buckley, Michael J.;Campbell, Jeffrey E.;Donnelly-Roberts, Diana L.;Gunther, Karen L.;Kim, David J. B.;Kuntzweiler, Theresa A.;Sullivan, James P.;Decker, Michael W.;Arneric, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1998.COA of Formula: C6H6ClNO This article mentions the following:
Analogs of A-98593 (I) and its enantiomer ABT-594 (II) with diverse substituents on the pyridine ring were prepared and tested for affinity to nicotinic acetylcholine receptor binding sites in rat brain and for analgesic activity in the mouse hot plate assay. Numerous types of modifications were consistent with high affinity for [3H]cytisine binding sites. By contrast, only selected modifications resulted in retention of analgesic potency in the same range as I and II. Analogs of II with one or two Me substituents at the 3-position of the azetidine ring also were prepared and substantially less active in both assays. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-methylpyridin-3-ol (cas: 218770-02-6COA of Formula: C6H6ClNO).
6-Chloro-2-methylpyridin-3-ol (cas: 218770-02-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H6ClNO