In 2022,Hood, Jacob C.; Tshikaya, Yannick; Manz, Aaren R.; LaPorte, Marcus C.; Klumpp, Douglas A. published an article in Journal of Organic Chemistry. The title of the article was 《Double Addition Reactions Involving Vinyl-Substituted N-Heterocycles and Active Methylene Compounds》.Application of 626-05-1 The author mentioned the following in the article:
A series of conjugate addition reactions was performed with vinyl-substituted N-heterocycles with active methylene compounds such as 1,3-dicarbonyl compounds, cyano esters, a cyano sulfone and malonyl nitrile to provide dipyridyl and related heterocyclic products I [R1 = R2 = H, (pyridin-4-yl)ethyl, (pyridin-2-yl)ethyl, (pyrazin-2-yl)ethyl, (quinolin-2-yl)ethyl, (quinoxalin-2-yl)ethyl; n = 0, 1; X = O, CH2, NMe; R1 = H, Me, R2 = H, Ph, 4-(Me)2NC6H4, etc.] in acid-catalyzed conversions. The Michael accepting groups included vinyl-substituted pyridines, quinoline, and pyrazine. Double conjugate addition reactions was accomplished with 2,6-divinylpyridine and related systems. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Application of 626-05-1)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 626-05-1