Horan, Alexandra M.; Duong, Vincent K.; McGarrigle, Eoghan M. published the artcile< Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts>, Related Products of 581-47-5, the main research area is bis heteroaryl preparation; halopyridine pyridylsulfonium salt coupling reaction.
Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E.
Organic Letters published new progress about Coupling reaction. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.