Synthesis of N-substituted sulfonamides containing perhalopyridine moiety as bio-active candidates was written by Hosseini, Raziyeh;Ranjbar-Karimi, Reza;Mohammadiannejad, Kazem. And the article was included in Journal of Fluorine Chemistry in 2020.Name: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
A series of N-perhalopyridyl sulfonamide derivatives I [R1 = H, Me; R2 = H, Et, nPr, Bn; R3 = pentafluoropyridin-4-yl, pentachloropyridin-4-yl] as bio-active candidates was synthesized from the reaction of the corresponding aryl sulfonamides with pentafluoro- and pentachloropyridines. Also, unlike aryl sulfonamides, the reaction of sulfamides with pentafluoro- and pentachloropyridines gave unexpected bis-perhalopyridin-4-ylamines II [R4 = R5 = pentafluoropyridin-4-yl, pentachloropyridin-4-yl]. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Name: 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2,3,4,5,6-Perfluoropyridine