Hou, Chuanfu; Sun, Shouneng; Liu, Ziqi; Zhang, Hui; Liu, Yue; An, Qi; Zhao, Jian; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi published an article in 2021. The article was titled 《Visible-Light-Induced Decarboxylative Acylation of Pyridine N-Oxides with α-Oxocarboxylic Acids Using Fluorescein Dimethylammonium as a Photocatalyst》, and you may find the article in Advanced Synthesis & Catalysis.Related Products of 626-05-1 The information in the text is summarized as follows:
The development of a visible-light-induced catalytic system achieved the decarboxylative acylation of pyridine N-oxides with α-oxocarboxylic acids, at room temperature and using the organic dye fluorescein dimethylammonium as a new type of photocatalyst was reported. A series of 2-arylacylpyridine N-oxides were selectively synthesized in moderate to good yields by controlling the polarity of the reaction solvent. The developed strategy was successfully applied in the synthesis of an important intermediate of the drug, acrivastine, on a gram scale. Notably, this is the first time that fluorescein dimethylammonium was used to catalyzed the Minisci-type C-H decarboxylative acylation reaction. The mechanism of decarboxylative acylation was studied by capturing adducts of acyl radicals and 1,1-diphenylethylene confirmed a radical mechanism. The disclosed catalytic system provided a green synthetic strategy for decarboxylative acylation without the use of addnl. oxidants or metal catalysts. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Related Products of 626-05-1)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 626-05-1