Computed Properties of C6H5NO. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators published in 2020.0, Reprint Addresses Thakur, GA (corresponding author), Northeastern Univ, Bouve Coll Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA.; Laprairie, RB (corresponding author), Univ Saskatchewan, Coll Pharm & Nutr, 104 Clin Pl, Saskatoon, SK S7N 2Z4, Canada.; Laprairie, RB (corresponding author), Dalhousie Univ, Fac Med, Dept Pharmacol, 5850 Coll St, Halifax, NS B3H 4R2, Canada.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.
Cannabinoid 1 receptor (CB1R) allosteric ligands hold a far-reaching therapeutic promise. We report the application of fluoro- and nitrogen-walk approaches to enhance the drug-like properties of GAT211, a prototype CB1R allosteric agonist-positive allosteric modulator (ago-PAM). Several analogs exhibited improved functional potency (cAMP, beta-arrestin 2), metabolic stability, and aqueous solubility. Two key analogs, GAT591 (6r) and GAT593 (6s), exhibited augmented allosteric-agonist and PAM activities in neuronal cultures, improved metabolic stability, and enhanced orthosteric agonist binding (CP55,940). Both analogs also exhibited good analgesic potency in the CFA inflammatory-pain model with longer duration of action over GAT211 while being devoid of adverse cannabimimetic effects. Another analog, GAT592 (9j), exhibited moderate ago-PAM potency and improved aqueous solubility with therapeutic reduction of intraocular pressure in murine glaucoma models. The SAR findings and the enhanced allosteric activity in this class of allosteric modulators were accounted for in our recently developed computational model for CB1R allosteric activation and positive allosteric modulation. [GRAPHICS] .
Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Garai, S; Kulkarni, PM; Schaffer, PC; Leo, LM; Brandt, AL; Zagzoog, A; Black, T; Lin, XY; Hurst, DP; Janero, DR; Abood, ME; Zimmowitch, A; Straiker, A; Pertwee, RG; Kelly, M; Szczesniak, AM; Denovan-Wright, EM; Mackie, K; Hohmann, AG; Reggio, PH; Laprairie, RB; Thakur, GA or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem