Quality Control of 3-Pyridinecarboxaldehyde. Recently I am researching about BAYLIS-HILLMAN REACTION; IN-VITRO; DRUG DISCOVERY; ISATINS; DERIVATIVES; HETEROCYCLES; MECHANISM; PARASITES; ADDUCTS; DESIGN, Saw an article supported by the FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/07600-3, 2018/02611-0, 2016/23005-6, 2015/09205-0]; CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [150306/2019-9, 140389/2016-4, 142476/2018-8, 422890/2016-2, 307840/2014-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Fernandes, FS; Santos, H; Lima, SR; Conti, C; Rodrigues, MT; Zeoly, LA; Ferreira, LLG; Krogh, R; Andricopulo, AD; Coelho, F. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde
A series of highly active hybrids were discovered as novel antiparasitic agents. Two heterocyclic scaffolds (1,2,4-oxadiazole and 3-hydroxy-2-oxindole) were linked, and the resulting compounds showed in vitro activities against intracellular amastigotes of two protozoan parasites, Tiypanosoma cruzi and Leishmania infantum. Their cytotoxicity was assessed using HFF-1 fibroblasts and HepG2 hepatocytes. Compounds 5b, 5d, 8h and 8o showed selectivity against L. infantum (IC50 values of 3.89, 2.38, 2.50 and 2.85 mu M, respectively). Compounds 4c, 4q, 8a and 8k were the most potent against T. cruzi, exhibiting IC50 values of 6.20, 2.20, 2.30 and 2.20 mu M, respectively. Additionally, the most potent anti-T. cruzi compounds showed in vitro efficacies comparable or superior to that of benznidazole. These easy-to-synthesize molecules represent novel chemotypes for the design of potent and selective lead compounds for Chagas disease and leishmaniasis drug discovery. (C) 2020 Elsevier Masson SAS. All rights reserved.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem