Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents was written by Hu, Laixing;Li, Zhuo-rong;Wang, Yue-ming;Wu, Yanbin;Jiang, Jian-Dong;Boykin, David W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application In Synthesis of 3-Amino-2,6-dimethoxypyridine This article mentions the following:
A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridin-3-yl)-9-ethyl- and 9-methylcarbazole-3-sulfonamide (I, R = Et, Me) gave significant cytotoxicity (IC50 = 122 and 101 nM). I (R = Et) displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides, which include the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring, are described. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application In Synthesis of 3-Amino-2,6-dimethoxypyridine).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 3-Amino-2,6-dimethoxypyridine