Hu, Min-Qi published the artcileA one-pot approach to construct 3-(2-methoxypyridin-3-yl)-4H-chromen-4-ones via meinwald rearrangement/intramolecular demethylation annulation of epoxides, Application In Synthesis of 71255-09-9, the main research area is methoxypyridinyloxiranyl methoxyphenylmethanone tandem one pot Meinwald demethylation heterocyclization; methoxypyridinyl chromenone preparation phenylboronic acid palladium catalyst Suzuki coupling; phenyl methoxypyridinyl chromenone preparation.
A convenient and practical approach for construction of 3-(2-methoxypyridin-3-yl)-4H-chromen-4-ones was successfully developed by a one-pot Meinwald rearrangement/intramol. demethylation/annulation reaction sequence with easily accessible epoxides as the starting material. The synthetic protocol was of excellent functional group compatibility under mild reaction conditions, and 3-(2-methoxypyridin-3-yl)-4H-chromen-4-ones were obtained in high yields. Moreover, further derivation successfully furnished more complicated derivatives by Suzuki-Miyaura cross-coupling reaction which may provide a promising potential application in exploring biol. activity of 3-aryl-4H-chromen-4-ones.
Heterocycles published new progress about Demethylation. 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Application In Synthesis of 71255-09-9.