Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Product Details of C5H3BrFN.
Huang, Adrian;Wo, Kellie;Lee, So Yeun Christine;Kneitschel, Nika;Chang, Jennifer;Zhu, Kathleen;Mello, Tatsiana;Bancroft, Laura;Norman, Natalie J.;Zheng, Shao-Liang research published 《 Regioselective Synthesis, NMR, and Crystallographic Analysis of N1-Substituted Pyrazoles》, the research content is summarized as follows. A systematic study of the N-substitution reactions of 3-substituted pyrazoles under basic conditions was undertaken. N1-Alkyl-, aryl-, and heteroarylpyrazoles were prepared regioselectively in 28-96% yields and in 3:1->99:1 regioselectivities by alkylation or arylation of 3-nitro-, 3-trifluoromethyl, 3-Me, 3-bromo-, 3-phenylpyrazoles and Et 3-pyrazolecarboxylate with alkyl bromides and iodides and electron-deficient aryl fluorides using K2CO3 as base in DMSO. DFT calculations of the at. charges at the pyrazole nitrogens in the pyrazolate anions were consistent with the observed regioselectivities; steric effects were observed in alkylations of pyrazoles. The structures of twenty-five of the pyrazole products were determined by X-ray crystallog.
Product Details of C5H3BrFN, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.