Huang, Chia-Yu; Stauffer, Tara M.; Strickland, Corey L.; Reader, John C.; Huang, He; Li, Ge; Cooper, Alan B.; Doll, Ronald J.; Ganguly, Ashit K.; Baldwin, John J.; Rokosz, Laura L. published the artcile< Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc>, Formula: C7H10N2, the main research area is piperazine derivative preparation structure farnesyltransferase inhibitor crystal structure.
Farnesyltransferase inhibitors identified from an ECLiPS library were optimized using solution-phase synthesis. X-ray crystallog. of inhibited complexes was used to identify substructures that coordinate to the active site zinc. The x-ray structures were ultimately used to guide the design of second-generation analogs with FTase IC50s of less than 1.0 nM.
Bioorganic & Medicinal Chemistry Letters published new progress about Conformation. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Formula: C7H10N2.