The author of ãCatalytic enantioselective borane reduction of benzyl oximes: preparation of (S)-1-pyridin-3-yl-ethylamine bis hydrochlorideã?were Huang, Kun; Ortiz-Marciales, Margarita. And the article was published in Organic Syntheses in 2010. Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride The author mentioned the following in the article:
The enantioselective preparation of (S)-1-(pyridin-3-yl)ethylamine bis hydrochloride is achieved by chiral spiroborate ester-catalyzed borane reduction of (E)-1-(pyridin-3-yl)ethanone O-benzyl-oxime in 88% yield, and 94% ee. In the part of experimental materials, we found many familiar compounds, such as (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride)
(S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 â?R2NâNO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride