Synthesis, Characterization, and In Vivo Evaluation of Desmethyl Anethole Trithione Phosphate Prodrug for Ameliorating Cerebral Ischemia-Reperfusion Injury in Rats was written by Huang, Sheng;Dong, Renhan;Xu, Gaojie;Liu, Jin;Gao, Xiaofang;Yu, Siqi;Qie, Pengfan;Gou, Gang;Hu, Min;Wang, Yu;Peng, Jian;Guang, Bing;Xu, Ying;Yang, Tai. And the article was included in ACS Omega in 2020.Safety of Pyridinehydrochloride This article mentions the following:
Anethole trithione (ATT) has a wide range of physiol. activities, but its use is limited due to its poor water solubility To improve the solubility of ATT, we synthesized and characterized a novel phosphate prodrug (ATXP) relying on the availability of the hydroxy group in 5-(4-hydroxyphenyl)-3H-1,2-dithiole3-thione (ATX), which was transformed from ATT rapidly and extensively in vivo. Our results showed that ATXP significantly improved drug solubility ATXP was rapidly converted to ATX and reached a maximum plasma concentration with a Tmax of approx. 5 min after i.v. (iv) administration. Furthermore, after the oral administration of ATXP, the Cmax was 3326.30 鍗?566.50 ng/mL, which was approx. 5-fold greater than that of the parent drug form, indicating that ATXP has greater absorption than that of ATT. Addnl., the oral phosphate prodrug ATXP increased the ATX in the area under the plasma concentration vs time curves (AUC0-t = 3927.40 鍗?321.50 and AUC0-閳?/sub> = 4579.0 鍗?756.30), making its use in practical applications more meaningful. Finally, compared to the vehicle, ATXP was confirmed to maintain the bioactivity of the parent drug for a significant reduction in infarct volume 24 h after reperfusion. Based on these findings, the phosphate prodrug ATXP is a potentially useful water-soluble prodrug with improved pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of Pyridinehydrochloride