Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt To Synthesize the Indenopyridine Core of Haouamine was written by Idzik, Tomasz J.;Borzyszkowska-Ledwig, Aleksandra;Struk, Lukasz;Sosnicki, Jacek G.. And the article was included in Organic Letters in 2019.COA of Formula: C5H3Br2NO This article mentions the following:
An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-aryl substituted indeno[2,1-b]pyridones (e.g. I), resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6COA of Formula: C5H3Br2NO).
3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C5H3Br2NO