As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10177-08-9, name is 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C12H9NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid
PREPARATION 52 2-Chloro-5-phenyl-3-pyridinecarboxylic acid To 191 g (0.98 mole) of phenyl phosphonic dichloride was added 66 g (0.31 mole) of 5-phenyl-2-pyridone-3-carboxylic acid and the reaction mixture heated to 135° C. for 2 hr. After cooling, the reaction mixture was poured into ~1.5 liter of water. To the mixture was added ~1 liter of tetrahydrofuran to partially solubilize the precipitate formed. The temperature was moderated with ice and 1 liter of water was added to complete the precipitation. The crude precipitate was collected and weighed 67 g (0.29 mole, 93percent). A sample was recrystallized from isopropyl alcohol to give white crystals, m.p. 239°-40° C. Analysis: Calculated for C12 H8 NO2 Cl: C, 61.69; H, 3.45; N, 6.00. Found: C, 61.68; H, 3.37; N, 5.97.
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Reference:
Patent; A. H. Robins Company, Inc.; US4705853; (1987); A;,
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