Reference of 102830-75-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 102830-75-1, name is 3-Bromo-5-chloro-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.
iNTERMEDIATE 16 (4S,5R)-5- 13 ,5-Bis(trifluoromethyl)phenyl] -3- 15-(5-chloro-2-methoxypyridin-3 -yl)-2-(methylthio?)pyrimidin-4-yl]methyH -4-methyl- 1,3 -oxazolidin-2-oneA dioxane (17.3 mL) solution of (4S,5R)-5- [3 ,5-bis(trifluoromethyl)phenyl] -4-methyl-3 – { [2- (methylsulfanyl)-5-(4,4,5,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)pyrimidin-4-yl]methyl} -1,3 – oxazolidin-2-one (II?1TERMEDIATE 21, 2.0 g, 3.46 mmol), 3-bromo-5-chloro-2- methoxypyridine (0.925 g, 4.16 mmol) and 2M potassium phosphate tribasic (3.5 mL, 7.00mmol) in a microwave vial was evacuated and charged three times with nitrogen. Then Pd(Ph3P)4 (0.400 g, 0.346 mmol) was added and the reaction vial was capped. The reaction was stirred for 10 minutes at 170C in a microwave reactor. LCMS showed complete conversion to the product. The reaction was diluted with acetonitrile (5 mL) and filtered through a 2g plug of RP C18 silica, rinsing with 10 mL acetonitrile. The filtrate was concentrated and the crude waspurified by silica gel chromatography, eluting with a gradient of 0-50% ethyl acetate/hexanes to give the title compound as a pale yellow foam. LCMS (M+H)*: 593.3
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 102830-75-1, 3-Bromo-5-chloro-2-methoxypyridine.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ACTON, John, J., III; YE, Feng; VACHAL, Petr; SHA, Deyou; DROPINSKI, James, F.; CHU, Lin; ONDEYKA, Debra; KIM, Alexander, J.; COLANDREA, Vincent, J.; ZANG, Yi; ZHANG, Fengqi; DONG, Guizhen; WO2013/165854; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem