Adding a certain compound to certain chemical reactions, such as: 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1064783-29-4, blongs to pyridine-derivatives compound. Formula: C5H2ClFN2O2
To the solution of 31 (1.0g, 4.2 mmol) in dried THF (10mL) was added potassium tert-butoxide (517.0 mg, 4.6mmol) , the miture was stirred at room temperature for 10min, then added 2-nitro-3-fluoro-5-chloropyridine (741.0 mg, 4.6 mmol) , and stirred at room temperature for 1h. The mixture was quenched by the addition of 10g silica gel, and purified by column chromatography to give the desired product (1.50g, 95%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1064783-29-4, its application will become more common.
Reference:
Patent; FUJIAN HAIXI PHARMACEUTICALS CO., LTD; FENG, Yan; WANG, Ruyong; LI, Junqing; ZHENG, Jianjia; LIAN, Xin; GONG, Xuan; FU, Yueli; KANG, Xinshan; (144 pag.)WO2019/174601; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem