Synthetic Route of 107351-82-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107351-82-6, name is 2-Bromo-5-phenylpyridine, molecular formula is C11H8BrN, molecular weight is 234.09, as common compound, the synthetic route is as follows.
Synthesis of Intermediate 14-B: Under nitrogen, in 250ml three-neck round bottom flask, Intermediate 14-A (7.02g, 0.03mol), and 120ml dried THF that underwent treatment with by Na / benzophenone were added. Liquid nitrogen was used to cool to -78C, then slowly added dropwise with stirring 14.5ml of n-butyllithium (0.036mol, 2.5mol·L-1), triisopropyl borate 9.96ml (8.12g, 0.043mol). After stirring to room temperature. Addition of an appropriate amount of dilute hydrochloric acid was added, extracted with ethyl acetate,The combined organic phases, the organic solvent was removed by rotary evaporation to give the crude product. And through recrystallization from ethanol as a white solid 3.92g, yield 65.7%.
Statistics shows that 107351-82-6 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-5-phenylpyridine.
Reference:
Patent; Kunshan Visionox Display Co., Ltd.; Tsinghua University; Beijing Weixinnuo Science And Technology Co., Ltd.; Qiu, Yong; Liu, Fei; Li, Yinkui; (36 pag.)CN102977129; (2016); B;,
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