Electric Literature of 1256791-13-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1256791-13-5, name is 1-(6-Chloro-5-methylpyridin-3-yl)ethanone, molecular formula is C8H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of compound l-(6-chloro-5-methyl-3-pyridyl)ethanone (850 mg), compound l-(3,5- dichloro-phenyl)-2,2,2-trifluoro-ethanone (1.82 g) and K2C03 (862mg) in 20 ml of dichloroethane was added Et3N (50 mg). The mixture was refluxed for 16 h. After cooling to 0C, Bu4N+Br” (322 mg), NH2OH.HCl (690 mg, 10 mmol) and NaOH (800 mg, 4 N) was added and the reaction mixture was stirred at room temperature for 16 h. Then, the reaction mixture was poured into diluted hydrochloric acid and extracted with ethyl acetate three times. The combined organic layers were dried over MgS04 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to give the title compound (1.6 g). lU NMR (300Mz, DMSO-d6): delta 2.39 (s, 3H), 4.37 (d, 1H), 4.43 (d, 1H), 7.62 (s, 2H), 7.83 (s, 1H), 8.17 (s, 1H), 8.55 (s, 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1256791-13-5, 1-(6-Chloro-5-methylpyridin-3-yl)ethanone.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; CASSAYRE, Jerome Yves; EL QACEMI, Myriem; LUKSCH, Torsten; RENOLD, Peter; WO2012/156400; (2012); A1;,
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