With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.132521-70-1, name is 6-(4-Methylpiperazin-1-yl)nicotinic acid, molecular formula is C11H15N3O2, molecular weight is 221.26, as common compound, the synthetic route is as follows.Computed Properties of C11H15N3O2
6-(4-methylpiperazin- 1 -yl)nicotinic acid (132 mg,0.6 mmol), tert-butyl 2-amino-4-(pyridin-4-yl) phenylcarbamate (172 mg, 0.6 mmol) and EDCI (346 mg, 1.8 mmol) were added into pyridine (5 ml). The mixture was stirred for overnight at room temperature. When the reaction finished, it was extracted by EA and washed by citric acid, NaHCO3 and saturated brine. Then the organic layer was concentrated to afford compound 2 (300 mg, crude).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,132521-70-1, 6-(4-Methylpiperazin-1-yl)nicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; Regenacy Pharmaceuticals, LLC; van Duzer, John H.; Mazitschek, Ralph; (123 pag.)US2018/141923; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem