Introduction of a new synthetic route about 13472-58-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13472-58-7, 3,5-Dichloro-2-methoxypyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 13472-58-7, 3,5-Dichloro-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3,5-Dichloro-2-methoxypyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 3,5-Dichloro-2-methoxypyridine

A solution of 3,5-dichloro-2-methoxypyridine (16 g, 90 mmol) in THF(100 mL) was slowly added to a solution of LDA (53.9 ml, 108 mmol) (2M in THF) at -78 C. DMF (14 mL, 180 mmol) was added to the reaction mixture and the resulting solution stirred at -78 C for about lh. The reaction mixture was then poured into a NH4C1 saturated aqueous solution. The aqueous layer was extracted with EtOAc (3 x 20 mL). The combined organic portion was dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure to give 3,5-dichloro-2-methoxyisonicotinaldehyde (17.54 g, 90 % ). LC/MS (Table 1, Method d) Rt = 1.86 min.; MS m/z: 205, 207 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13472-58-7, 3,5-Dichloro-2-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; ABBVIE INC.; ARGIRIADI, Maria A.; BREINLINGER, Eric; CUSACK, Kevin P.; HOBSON, Adrian, D.; POTIN, Dominique; BARTH, Martine; AMAUDRUT, Jerome; POUPARDIN, Olivia; MOUNIER, Laurent; KORT, Michael, E.; (392 pag.)WO2016/198908; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem