Electric Literature of 136888-79-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 136888-79-4, name is 2-Fluoro-5-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of DIPEA (54.0 mL, 385 mmol) in THF (1101 mL, 385 mmol) at – 60 C was added BuLi, 2.5 M in hexanes (154 mL, 385 mmol) over 5 minutes such that the internal temperature was maintained below – 60 C. After stirring for 45 minutes at -65 C a solution of 2-fluoro-5-methoxypyridine (49 g, 385 mmol) in 200 mL of THF was added over the course of 2 minutes maintaining an internal temperature < -65 C. The reaction was stirred at -70 C for 1.5 hours then reaction was poured into a 3 L flask containing 1200 g of crushed dry ice. The reaction was allowed to warm to 0 C and then poured into 1000 mL of water. The organics were removed under reduced pressure and the aqueuous layer was acidified with 1100 mL of 2 N HC1. The resulting thick white slurry was stirred for 1 hour then filtered to provide 2-fluoro-5-methoxynicotinic acid as a white solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 136888-79-4, 2-Fluoro-5-methoxypyridine.
Reference:
Patent; AMGEN INC.; DINEEN, Thomas; WEISS, Matthew; PATEL, Vinod F.; ZHENG, Xiao Mei; WHITE, Ryan; WO2012/109165; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem