Introduction of a new synthetic route about 1513-65-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1513-65-1, its application will become more common.

Reference of 1513-65-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1513-65-1 as follows.

Example 13: (4S)-Lambda/-Methyl-Lambda/-(f5-(4-methyl-1-piperazinvnimidazo? .2-aloyridin-2- v?methyl)-3,4-dihvdro-2H-pyranof3,2-b1pyridin-4-arnine EPO A) 6-Fluoro-2-pyridinamine: A solution of 2,6-difluoropyridine (50 g, 434 mmol) in ammonium hydroxide (200 mL, 28.0- 30.0%) was heated at 1050C in a steel bomb for 15 hours. The reaction was cooled in an ice bath and the precipitate filtered, rinsed with cold water, and dried to yield 6-fluoro-2- pyridinamine (45.8 g, 94% yield) as a white solid. 1H-NMR (CDCI3): delta 7.53 (m, 1 H)1 6.36 (dd, 1 H), 6.26 (dd, 1 H), 4.56 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1513-65-1, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/76131; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem