Synthetic Route of 15862-31-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-31-4, name is 3-Bromo-5-nitropyridin-2-amine, molecular formula is C5H4BrN3O2, molecular weight is 218.01, as common compound, the synthetic route is as follows.
Compound 1 (2.6 g, 12.52 mmol) and iodo benzene (2.5 g,13.77 mmol )were dissolved in Toluene( 25 m) and the solution was degassed with argon. Palladium acetate (0.28 g, 6.26 mmol ) ,xanthaphos (0.545 g, 1.252 mmol) , sodium tertiary butaoxide(l .65 g, 18.78 mmol )were added. The reaction was heated at reflux under argon for 2h.The solvent was removed in vacuum and crude mass was purified by column chromatography by eluting with 20percent ethyl acetate in pet ether to get desired compound 2 ( 1 g )
Statistics shows that 15862-31-4 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-nitropyridin-2-amine.
Reference:
Patent; VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita; WO2013/42035; (2013); A1;,
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