Reference of 17282-40-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17282-40-5, name is 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium bromide, molecular formula is C9H12BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
27G. Methyl (4-(6-(l-((tert-butoxycarbonyl)amino)but-3-en-l-yl)-2-oxo-l,2- dihydropyridin-4-yl)-3-nitrophenyl)carbamate: To a solution of 27F (3.0 g, 7.15 mmol) and l-(2-ethoxy-2-oxoethyl)pyridinium bromide (1.189 g, 7.15 mmol) in EtOH (130 mL), was added ammonium acetate (11.03 g, 143 mmol) portion wise. After 15 min, the mixture was stirred at 75 C. The reaction mixture was then concentrated and dissolved in EtOAc. The organic layer was then washed with 1.0 N HC1, H20, saturated sodium bicarbonate solution and finally by brine. The organic phase was dried over sodium sulfate, filtered and concentrated to yield a residue which was purified by normal phase chromatography to isolate the desired product (2.2 g, 67%) as a brown solid. MS (ESI) m/z: 459.3 (M+H)+.
According to the analysis of related databases, 17282-40-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LAM, Patrick Y.S.; CLARK, Charles G.; CORTE, James R.; EWING, William R.; GILLIGAN, Paul J.; JEON, Yoon; YANG, Wu; SMITH, Leon, M., II.; WANG, Yufeng; WO2013/22814; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem