Reference of 175205-81-9, Adding some certain compound to certain chemical reactions, such as: 175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine,molecular formula is C6H3BrF3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175205-81-9.
General procedure: Aryl or heteroaryl bromide (4 mmol) was charged in oven dried Radley’s synthesis tube that was equipped with a stir bar under a stream of nitrogen. Anhydrous diethyl ether was added and the reaction mixture was cooled to -78 ¡ãC. n-BuLi (1.6 M in hexanes, 2.5 mL, 4.00 mmol) was added dropwise and the reaction mixture was stirred at -78 ¡ãC for 10 min. A solution of aryl or heteroaryl nitrile in THF (4 mmol) was added dropwise and the reaction mixture was stirred at -78 ¡ãC for 2 h. TMSCl (0.550 mL, 4.00 mmol) was added to the reaction mixture at -78 ¡ãC and the reaction mixture was allowed to warm up to 0 ¡ãC. The reaction mixture was cooled to -78 ¡ãC, benzylmagnesium chloride in either THF or ether (2 mmol) or benzyl zinc(II) bromide in ether (2 mmol), was added dropwise, stirred at -78 ¡ãC for 2 h, and then stirred at rt for 12 h. The reaction mixture was worked up and purified as in general procedure 1.
According to the analysis of related databases, 175205-81-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kamau, Muthoni G.; Harikrishnan, Lalgudi S.; Finlay, Heather J.; Qiao, Jennifer X.; Jiang, Ji; Poss, Michael A.; Salvati, Mark E.; Wexler, Ruth R.; Lawrence, R. Michael; Tetrahedron; vol. 68; 12; (2012); p. 2696 – 2703;,
Pyridine – Wikipedia,
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