Introduction of a new synthetic route about 19798-80-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-80-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 19798-80-2, 4-Chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19798-80-2, blongs to pyridine-derivatives compound. Quality Control of 4-Chloropyridin-2-amine

To a solution of 4-chloropyridin-2-amine (5.0 g, 39 mmol) in MeCN (200 mL) at 0 C was added B (2.2 mL, 43 mmol) in portions over a period of 30 min. The reaction was warmed to rt and stirred overnight. The solid was filtered, washed with hexane (3x), and dried to afford Intermediate 12A (9.1 g, 81%) as an off-white solid. LC-MS (ESI) m/z: 206.9/208.9 [M+H]+; ‘H NMR (400MHZ, DMSO-d6) delta 8.30 (s, 1H), 7.02 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-80-2, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; QUAN, Mimi L.; HU, Zilun; WANG, Cailan; PATIL, Sharanabasappa; WO2015/2915; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem