Electric Literature of 22918-01-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 22918-01-0 as follows.
To a solution of 2-bromo-4-chloropyridine (1.0 g, 5.2 mmol) in DMSO (10 mL) was added sodium methanolate (0.35 g, 6.48 mmol). After the addition, the mixture was stirred at 120 C for 24 h. The reaction was cooled to rt and extracted with EtOAc. The combined organic layers were dried (Na2S04) and concentrated under reduced pressure. The residue was purified via prep-HPLC to afford 2-bromo-4-methoxypyridine (0.25 g, 25 %) as colorless oil. MS ESI calc’d. For C6H6BrNO [M + H]+ 189 found 189.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22918-01-0, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ANDRESEN, Brian, M.; ANTHONY, Neville, J.; MILLER, Thomas, A.; WO2014/74422; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem