With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine, molecular formula is C6H3BrF3N, molecular weight is 225.99, as common compound, the synthetic route is as follows.Quality Control of 2-Bromo-4-(trifluoromethyl)pyridine
A mixture of 2-bromo-4-(trifluoromethyl)pyridine (1.04 g, 4.58 mmol), dithieno[3,2-b:2′,3′-d] thiophene-2-boronic acid (1.00 g, 4.16 mmol), Pd(PPh3)4 (0.19 g, 0.167 mmol,4molpercent), anhydrous sodium carbonate (1.73 g, 12.5 mmol), aliquat 336 (0.67 g, 1.67 mmol),tetrahydrofuran (80 mL), and water (50 mL) was headed under a nitrogen atmosphere at80?C for 24 h. This reaction is the Suzuki coupling reaction. After, the organic mixturesolids were collected by a glass filter (G4), the reaction mixture was washed with hexane,water, and methanol several times and dried in a vacuum. Yield: 53.6percent (0.766 g); 1HNMR(CDCl3, 500 MHz): deltaH(ppm) 8.47(s, 1H), 8.12(s, 1H), 7.51(s, 1H), 7.25(s, 1H), 7.25(s,1H), 6.96(s, 1H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,175205-81-9, 2-Bromo-4-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Article; Park, Sang-Yong; Lee, Sang-Wook; Shin, Dong-Myung; Molecular Crystals and Liquid Crystals; vol. 620; 1; (2015); p. 132 – 138;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem