Reference of 791644-48-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 791644-48-9, name is 2-Chloro-5-fluoronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
Example 4A5-Fluoro-lH-pyrazolo[3,4-b]pyridin-3-amineA suspension of 38.5 g (245.93 mmol) of 2-chloro-5-fluoronicotinonitrile was introduced in 1,2-ethanediol (380 ml) and subsequently admixed with hydrazine hydrate (1 19.6 ml, 2.459 mol) The mixture was heated at reflux with stirring for 4 h. On cooling, the product precipitated. The yellow crystals were admixed with water (380 ml) and subjected to extractive stirring at RT for 10 min. Then the suspension was filtered with suction over a frit, and the filter product was washed with water (200 ml) and with -10C cold THF (200 ml). The residue was dried under a high vacuum over phosphorus pentoxide.Yield: 22.8 g (61% of theory) .H NMR (400 MHz, DMSO-d6): delta = 5.54 (s, 2H), 7.96 (dd, 1H), 8.38 (m, 1H), 12.07(m, 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 791644-48-9, 2-Chloro-5-fluoronicotinonitrile.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HIRTH-DIETRICH, Claudia; SANDNER, Peter; STASCH, Johannes-Peter; KNORR, Andreas; VON DEGENFELD, Georges; HAHN, Michael; FOLLMANN, Markus; WO2011/147810; (2011); A1;,
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